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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
TPH2
All Species:
32.42
Human Site:
Y203
Identified Species:
50.95
UniProt:
Q8IWU9
Number Species:
14
Phosphosite Substitution
Charge Score:
0.07
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q8IWU9
NP_775489.2
490
56057
Y203
D
V
A
M
G
Y
K
Y
G
Q
P
I
P
R
V
Chimpanzee
Pan troglodytes
XP_522470
490
55999
Y203
D
V
A
M
G
Y
K
Y
G
Q
P
I
P
R
V
Rhesus Macaque
Macaca mulatta
Q2HZ26
490
56076
Y203
D
V
A
M
G
Y
K
Y
G
Q
P
I
P
R
V
Dog
Lupus familis
XP_538286
708
77776
Y420
D
V
A
M
G
Y
K
Y
G
Q
P
I
P
R
V
Cat
Felis silvestris
Mouse
Mus musculus
Q8CGV2
488
55899
Y201
D
V
A
M
G
Y
K
Y
G
Q
P
I
P
R
V
Rat
Rattus norvegicus
Q8CGU9
485
55603
Y198
D
V
A
M
G
Y
K
Y
G
Q
P
I
P
R
V
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001519524
444
50785
K163
K
H
G
D
P
I
P
K
I
E
F
T
E
E
E
Chicken
Gallus gallus
P70080
445
51121
E164
K
H
G
D
P
I
P
E
I
E
F
T
E
E
E
Frog
Xenopus laevis
Q92142
481
55388
Y194
D
V
A
M
S
Y
K
Y
G
D
P
I
P
H
I
Zebra Danio
Brachydanio rerio
NP_999960
473
54279
P189
M
N
Y
K
F
G
Q
P
I
P
R
I
E
Y
T
Tiger Blowfish
Takifugu rubipres
NP_001027849
486
55494
F199
E
V
A
M
N
Y
K
F
G
Q
P
I
P
R
V
Fruit Fly
Dros. melanogaster
P17276
452
51642
E171
A
Y
N
Y
K
H
G
E
P
L
P
H
V
D
Y
Honey Bee
Apis mellifera
XP_394674
508
57954
Y197
D
I
A
N
N
Y
R
Y
G
Q
A
I
P
R
V
Nematode Worm
Caenorhab. elegans
P90925
457
52111
T176
K
H
G
D
K
I
P
T
I
T
Y
T
D
E
E
Sea Urchin
Strong. purpuratus
XP_784134
479
54807
S192
D
V
S
H
D
V
N
S
G
N
I
I
P
R
V
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99.5
98.7
58.9
N.A.
93
93.6
N.A.
68.3
68.5
68.7
72.2
80
48.5
56.6
46.7
53.2
Protein Similarity:
100
99.5
99.1
63.7
N.A.
95.3
96.7
N.A.
79.8
80.8
83.2
83
88.5
66.1
70.8
65.5
69.5
P-Site Identity:
100
100
100
100
N.A.
100
100
N.A.
0
0
73.3
6.6
80
6.6
66.6
0
46.6
P-Site Similarity:
100
100
100
100
N.A.
100
100
N.A.
6.6
6.6
80
13.3
93.3
13.3
80
0
53.3
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
7
0
60
0
0
0
0
0
0
0
7
0
0
0
0
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
60
0
0
20
7
0
0
0
0
7
0
0
7
7
0
% D
% Glu:
7
0
0
0
0
0
0
14
0
14
0
0
20
20
20
% E
% Phe:
0
0
0
0
7
0
0
7
0
0
14
0
0
0
0
% F
% Gly:
0
0
20
0
40
7
7
0
67
0
0
0
0
0
0
% G
% His:
0
20
0
7
0
7
0
0
0
0
0
7
0
7
0
% H
% Ile:
0
7
0
0
0
20
0
0
27
0
7
74
0
0
7
% I
% Lys:
20
0
0
7
14
0
54
7
0
0
0
0
0
0
0
% K
% Leu:
0
0
0
0
0
0
0
0
0
7
0
0
0
0
0
% L
% Met:
7
0
0
54
0
0
0
0
0
0
0
0
0
0
0
% M
% Asn:
0
7
7
7
14
0
7
0
0
7
0
0
0
0
0
% N
% Pro:
0
0
0
0
14
0
20
7
7
7
60
0
67
0
0
% P
% Gln:
0
0
0
0
0
0
7
0
0
54
0
0
0
0
0
% Q
% Arg:
0
0
0
0
0
0
7
0
0
0
7
0
0
60
0
% R
% Ser:
0
0
7
0
7
0
0
7
0
0
0
0
0
0
0
% S
% Thr:
0
0
0
0
0
0
0
7
0
7
0
20
0
0
7
% T
% Val:
0
60
0
0
0
7
0
0
0
0
0
0
7
0
60
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
7
7
7
0
60
0
54
0
0
7
0
0
7
7
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _